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The most common side effects reported in SURPASS 1 trial (as compared with placebo) were abdominal discomfort, nausea, diarrhoea (1218%), injection site reactions (23%), and hypersensitivity (12%)

In practice, clinics adapt trial titration schedules by starting most patients at 1 mg once weekly for 24 weeks, which is considered the safest entry point for minimizing GI side effects

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As noted previously, Huperzine A's long half-life means the compound accumulates with daily use daily dosing at the full two-scoop Lightning serving is not advisable without periodic cycling.